Anti-CD38抗體詳細說明書

【資料簡介】

產品類別     產品目錄 >>  一抗 >>  一抗
相關標記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin   Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC  
英文名稱     Anti-CD38
中文名稱     CD38抗體
別    名     Acute lymphoblastic leukemia cells antigen CD38; ADP ribosyl cyclase 1; ADP ribosyl cyclase; ADP ribosyl cyclase/cyclic ADP-ribose hydrolase; CADPr hydrolase 1; CD 38; CD38 antigen; Cd38-rs1; CD38H; Cyclic ADP ribose hydrolase 1; I-19; Lymphocyte differentiation antigen CD38; NIM-R5 antigen; NIMR5 antigen (mouse); p45; T10.
濃    度     1mg/1ml
克隆類型     polyclonal
交叉反應     Mouse, Rat, 
產品類型     一抗  
研究領域     腫瘤 免疫學 干細胞 糖尿病 細胞表面分子 自然殺傷細胞 淋巴細胞 t-淋巴細胞 b-淋巴細胞
蛋白分子量     predicted molecular weight: 34kDa
性    狀     Lyophilized or Liquid
免 疫 原     KLH conjugated synthetic peptide derived from mouse CD38 (101-150aa)
亞    型     IgG
純化方法     affinity purified by Protein A
儲 存 液     0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用      WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  Flow-Cyt=1:100-500  IF=1:100-500 
（石蠟切片需做抗原修復）

 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.
保存條件     Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note     This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關產品     免疫組化常用試劑    免疫印跡常用試劑    各種標記二抗

產品介紹：
CD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion, signal transduction and calcium signaling. CD38 antigen is an integral membrane glycoprotein, M.W. 45 kD. The CD38 antigen is present on approximay all pre-B lymphocytes, plasma cells and thymocytes. CD38 antigen is also expressed on activated T Lymphocytes, NK Cells, monocytes, myeloblasts and erythroblasts. CD38 is co-expressed on CD34+ cells,but is not expressed on pluripotent stem cells. CD38 antigen is present on T and B lymphoblastic leukemia (ALL), Burkitts' lymphoma, multiple myeloma and acute myeloid leukemia (AML).
Function : Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Subcellular Location : Membrane; Single-pass type II membrane protein.
Tissue Specificity : Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.
Similarity : Belongs to the ADP-ribosyl cyclase family.
CD38分子是單鏈Ⅱ型跨膜糖蛋白，存在于很多免疫細胞表面上,CD38與無脊椎動物卵的授精、HIV感染、某些癌癥以及糖尿病等有關，CD38具有許多復雜而又*的生物學特性及功能，有調控細胞鈣釋放的機制。主要表達于胸腺細胞、前T和前B細胞、活化的T和B細胞、單核細胞、NK細胞、漿細胞等，可用于急性白血病的分型和活化的T細胞在自身免疫和免疫缺陷中的作用等方面的研究，也可作為生發中心B細胞的一種選擇性標記。 
產品圖片    

Antigen: bs-0979P, 0.2ug/100ul 
Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; 
Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; 
TMB(C-0024) staining; 
Read the data in MicroplateReader by 450nm.